5AHF

Crystal structure of Salmonella enterica HisA D7N with ProFAR

Summary for 5AHF

Entry DOI	10.2210/pdb5ahf/pdb
Related	5AHE 5AHI
Descriptor	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, GLYCEROL, ... (4 entities in total)
Functional Keywords	isomerase, hisa, histidine biosynthesis
Biological source	Salmonella enterica
Cellular location	Cytoplasm: A0A5T2G6F4
Total number of polymer chains	1
Total formula weight	27892.46
Authors	Soderholm, A.,Guo, X.,Newton, M.S.,Evans, G.B.,Nasvall, J.,Patrick, W.M.,Selmer, M. (deposition date: 2015-02-05, release date: 2015-09-02, Last modification date: 2024-05-08)
Primary citation	Soderholm, A.,Guo, X.,Newton, M.S.,Evans, G.B.,Nasvall, J.,Patrick, W.M.,Selmer, M. Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa J.Biol.Chem., 290:24657-, 2015 Cited by PubMed: 26294764 DOI: 10.1074/JBC.M115.678086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.201 Å)

Structure validation