5ACB
Crystal Structure of the Human Cdk12-Cyclink Complex
Summary for 5ACB
Entry DOI | 10.2210/pdb5acb/pdb |
Descriptor | CYCLIN-K, CYCLIN-DEPENDENT KINASE 12, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus: Q9NYV4 |
Total number of polymer chains | 4 |
Total formula weight | 141446.32 |
Authors | Dixon Clarke, S.E.,Elkins, J.M.,Pike, A.C.W.,Mackenzie, A.,Goubin, S.,Strain-Damerell, C.,Mahajan, P.,Tallant, C.,Chalk, R.,Wiggers, H.,Kopec, J.,Fitzpatrick, F.,Burgess-Brown, N.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2015-08-14, release date: 2016-06-15, Last modification date: 2016-10-05) |
Primary citation | Zhang, T.,Kwiatkowski, N.,Olson, C.M.,Dixon-Clarke, S.E.,Abraham, B.J.,Greifenberg, A.K.,Ficarro, S.B.,Elkins, J.M.,Liang, Y.,Hannett, N.M.,Manz, T.,Hao, M.,Bartkowiak, B.,Greenleaf, A.L.,Marto, J.A.,Geyer, M.,Bullock, A.N.,Young, R.A.,Gray, N.S. Covalent Targeting of Remote Cysteine Residues to Develop Cdk12 and Cdk13 Inhibitors. Nat.Chem.Biol., 12:876-, 2016 Cited by PubMed: 27571479DOI: 10.1038/NCHEMBIO.2166 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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