5AAD
Aurora A kinase bound to an imidazopyridine inhibitor (7a)
Summary for 5AAD
Entry DOI | 10.2210/pdb5aad/pdb |
Related | 5AAE 5AAF 5AAG |
Descriptor | AURORA KINASE A, 7-(1-benzyl-1H-pyrazol-4-yl)-6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase, aurora-a, imidazopyridine, aurora kinase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 33480.65 |
Authors | McIntyre, P.J.,Kosmopoulou, M.,Bayliss, R. (deposition date: 2015-07-24, release date: 2015-09-02, Last modification date: 2024-01-10) |
Primary citation | Bavetsias, V.,Perez-Fuertes, Y.,Mcintyre, P.J.,Atrash, B.,Kosmopoulou, M.,O'Fee, L.,Burke, R.,Sun, C.,Faisal, A.,Bush, K.,Avery, S.,Henley, A.,Raynaud, F.I.,Linardopoulos, S.,Bayliss, R.,Blagg, J. 7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent. Bioorg.Med.Chem.Lett., 25:4203-, 2015 Cited by PubMed: 26296477DOI: 10.1016/J.BMCL.2015.08.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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