5A83
Crystal structure of human ATAD2 bromodomain in complex with 4-((3R, 4R)-4-3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydroquinolin-8- yl-aminopiperidin-3-yloxymethyl)-1-thiane-1,1-dione
Summary for 5A83
Entry DOI | 10.2210/pdb5a83/pdb |
Related | 5A81 5A82 5A85 |
Descriptor | ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, 8-[[(3R,4R)-3-[[1,1-bis(oxidanylidene)thian-4-yl]methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-quinolin-2-one, ... (5 entities in total) |
Functional Keywords | hydrolase, inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2 |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 16342.49 |
Authors | Chung, C.,Bamborough, P.,Demont, E. (deposition date: 2015-07-11, release date: 2015-08-12, Last modification date: 2024-05-08) |
Primary citation | Bamborough, P.,Chung, C.,Furze, R.C.,Grandi, P.,Michon, A.,Sheppard, R.J.,Barnett, H.,Diallo, H.,Dixon, D.P.,Douault, C.,Jones, E.J.,Karamshi, B.,Mitchell, D.J.,Prinjha, R.K.,Rau, C.,Watson, R.J.,Werner, T.,Demont, E.H. Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors. J.Med.Chem., 58:6151-, 2015 Cited by PubMed: 26230603DOI: 10.1021/ACS.JMEDCHEM.5B00773 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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