5A3U

HIF prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 6-(5-oxo-4-(1H- 1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid

Summary for 5A3U

• Entry DOI: 10.2210/pdb5a3u/pdb
• Related: 2G19 2G1M 4BQW 4BQX 4BQY
• Descriptor: EGL NINE HOMOLOG 1, MANGANESE (II) ION, 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid (3 entities in total)
• Functional Keywords: oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 3
• Total formula weight: 85272.30

Authors

Chowdhury, R.,Gomez-Perez, V.,Schofield, C.J. (deposition date: 2015-06-03, release date: 2015-06-17, Last modification date: 2024-01-10)

• Primary citation: Chan, M.C.,Atasoylu, O.,Hodson, E.,Tumber, A.,Leung, I.K.H.,Chowdhury, R.,Gomez-Perez, V.,Demetriades, M.,Rydzik, A.M.,Holt-Martyn, J.,Tian, Y.,Bishop, T.,Claridge, T.D.W.,Kawamura, A.,Pugh, C.W.,Ratcliffe, P.J.,Schofield, C.J.; Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.; Plos One, 10:32004-, 2015; PubMed: 26147748; DOI: 10.1371/JOURNAL.PONE.0132004

Experimental method

X-RAY DIFFRACTION (3.3 Å)