5A0Q

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

Summary for 5A0Q

Entry DOI	10.2210/pdb5a0q/pdb
EMDB information	2981
Descriptor	PROTEASOME SUBUNIT ALPHA TYPE-6, PROTEASOME SUBUNIT BETA TYPE-3, PROTEASOME SUBUNIT BETA TYPE-2, ... (15 entities in total)
Functional Keywords	hydrolase, proteasome, 20s, adaahx3l3vs, ligand, inhibitor, drug design
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm : P60900 P49720 P49721 P28074 P20618 P28070 P25787 P25789 O14818 P28066 P25786 P25788 P28072 Q99436
Total number of polymer chains	28
Total formula weight	723185.21
Authors	daFonseca, P.C.A.,Morris, E.P. (deposition date: 2015-04-22, release date: 2015-12-30, Last modification date: 2017-08-02)
Primary citation	Da Fonseca, P.C.A.,Morris, E.P. Cryo-Em Reveals the Conformation of a Substrate Analogue in the Human 20S Proteasome Core. Nat.Commun., 6:7573-, 2015 Cited by PubMed: 26133119 DOI: 10.1038/NCOMMS8573 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation