5A0E

Crystal structure of cyclophilin D in complex with CsA analogue, JW47.

Summary for 5A0E

Entry DOI	10.2210/pdb5a0e/pdb
Descriptor	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL, JW47 (3 entities in total)
Functional Keywords	isomerase, cyclophilin d, cyp d, ppif, cyclosporin a, csa, jw47, mitochondrial permeability transition pore, ptp, peptidylprolyl cis-trans isomerase, cyclophilin
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	38232.07
Authors	Warne, J.,Pryce, G.,Hill, J.,Shi, X.,Lenneras, F.,Puentes, F.,Kip, M.,Hilditch, L.,Walker, P.,Simone, M.,Chan, A.W.E.,Towers, G.,Coker, A.R.,Duchen, M.,Szabadkai, G.,Baker, D.,Selwood, D.L. (deposition date: 2015-04-19, release date: 2015-12-30, Last modification date: 2024-01-10)
Primary citation	Warne, J.,Pryce, G.,Hill, J.,Shi, X.,Lenneras, F.,Puentes, F.,Kip, M.,Hilditch, L.,Walker, P.,Simone, M.I.,Chan, A.W.E.,Towers, G.J.,Coker, A.R.,Duchen, M.R.,Szabadkai, G.,Baker, D.,Selwood, D.L. Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects Against Neuro-Degeneration in Experimental Multiple Sclerosis. J.Biol.Chem., 291:4356-, 2016 Cited by PubMed: 26679998 DOI: 10.1074/JBC.M115.700385 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation