4ZVZ
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Summary for 4ZVZ
Entry DOI | 10.2210/pdb4zvz/pdb |
Related | 4ZX2 |
Descriptor | Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1R,2S,3R,4S,5S)-5-(propoxymethyl)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ... (6 entities in total) |
Functional Keywords | protein phosphatase 5, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P53041 |
Total number of polymer chains | 4 |
Total formula weight | 153255.89 |
Authors | Chattopadhyay, D.,Swingle, M.R.,Salter, E.A.,Wierzbicki, A.,Honkanen, R.E. (deposition date: 2015-05-18, release date: 2016-04-27, Last modification date: 2023-09-27) |
Primary citation | Chattopadhyay, D.,Swingle, M.R.,Salter, E.A.,Wood, E.,D'Arcy, B.,Zivanov, C.,Abney, K.,Musiyenko, A.,Rusin, S.F.,Kettenbach, A.,Yet, L.,Schroeder, C.E.,Golden, J.E.,Dunham, W.H.,Gingras, A.C.,Banerjee, S.,Forbes, D.,Wierzbicki, A.,Honkanen, R.E. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem. Pharmacol., 109:14-26, 2016 Cited by PubMed: 27002182DOI: 10.1016/j.bcp.2016.03.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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