4ZSA
Crystal structure of FGFR1 kinase domain in complex with 7n
Summary for 4ZSA
Entry DOI | 10.2210/pdb4zsa/pdb |
Descriptor | Fibroblast growth factor receptor 1, 4-(4-ethylpiperazin-1-yl)-N-[6-(3-methoxyphenyl)-2H-indazol-3-yl]benzamide (3 entities in total) |
Functional Keywords | fgfr1 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71067.67 |
Authors | |
Primary citation | Liu, J.,Peng, X.,Dai, Y.,Zhang, W.,Ren, S.,Ai, J.,Geng, M.,Li, Y. Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold. Org.Biomol.Chem., 13:7643-7654, 2015 Cited by PubMed: 26080733DOI: 10.1039/c5ob00778j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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