4ZO1
Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha
Summary for 4ZO1
Entry DOI | 10.2210/pdb4zo1/pdb |
Descriptor | Thyroid hormone receptor beta, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, ligand binding, protein-ligand complex, protein binding |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P10828 P19793 |
Total number of polymer chains | 3 |
Total formula weight | 55562.81 |
Authors | Bruning, J.B.,Kojetin, D.J.,Matta-Camacho, E.,Hughes, T.S.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Nowak, J.,Chalmers, M.J.,Marciano, D.P.,Kamenecka, T.M.,Rance, M.,Shulman, A.I.,Mangelsdorf, D.J.,Griffin, P.R.,Nettles, K.W. (deposition date: 2015-05-05, release date: 2015-09-02, Last modification date: 2023-11-15) |
Primary citation | Kojetin, D.J.,Matta-Camacho, E.,Hughes, T.S.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Nowak, J.,Chalmers, M.J.,Marciano, D.P.,Kamenecka, T.M.,Shulman, A.I.,Rance, M.,Griffin, P.R.,Bruning, J.B.,Nettles, K.W. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nat Commun, 6:8013-8013, 2015 Cited by PubMed: 26289479DOI: 10.1038/ncomms9013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.221 Å) |
Structure validation
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