4ZFO

J22.9-xi: chimeric mouse/human antibody against human BCMA (CD269)

Summary for 4ZFO

Entry DOI	10.2210/pdb4zfo/pdb
Descriptor	Tumor necrosis factor receptor superfamily member 17, J22.9-xi Fab, Light Chain, J22.9-xi Fab, Heavy Chain, ... (7 entities in total)
Functional Keywords	antibody fab-ligand complex anti-bcma anti-tumor, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Single-pass type III membrane protein: Q02223
Total number of polymer chains	6
Total formula weight	106712.63
Authors	Marino, S.F.,Daumke, O.,Olal, D. (deposition date: 2015-04-21, release date: 2015-05-20, Last modification date: 2024-01-10)
Primary citation	Oden, F.,Marino, S.F.,Brand, J.,Scheu, S.,Kriegel, C.,Olal, D.,Takvorian, A.,Westermann, J.,Yilmaz, B.,Hinz, M.,Daumke, O.,Hopken, U.E.,Muller, G.,Lipp, M. Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma. Mol Oncol, 9:1348-1358, 2015 Cited by PubMed: 25953704 DOI: 10.1016/j.molonc.2015.03.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.895 Å)

Structure validation