4Z9L

THE STRUCTURE OF JNK3 IN COMPLEX WITH AN IMIDAZOLE-PYRIMIDINE INHIBITOR

Replaces:  1PMQ

Summary for 4Z9L

• Entry DOI: 10.2210/pdb4z9l/pdb
• Related: 1PMQ
• Descriptor: Mitogen-activated protein kinase 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, CYCLOHEXYL-{4-[5-(3,4-DICHLOROPHENYL)-2-PIPERIDIN-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE, ... (5 entities in total)
• Functional Keywords: map kinase, apoptosis, inhibition, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P53779
• Total number of polymer chains: 1
• Total formula weight: 43021.34

Authors

Scapin, G.,Patel, S.B.,Lisnock, J.,Becker, J.W.,Lograsso, P.V.,Smart, O.S.,Bricogne, G. (deposition date: 2015-04-10, release date: 2015-05-06, Last modification date: 2023-09-27)

• Primary citation: Scapin, G.,Patel, S.B.,Lisnock, J.,Becker, J.W.,LoGrasso, P.V.; The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.; Chem.Biol., 10:705-712, 2003; PubMed: 12954329

Experimental method

X-RAY DIFFRACTION (2.1 Å)