4Z41

X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Compound with a S,O Bidentate Ligand (9a=Chloro-(1-(3'-hydroxy)-3-(methylthio)-3-thioxo-prop-1-en-1-olate-O,S)-(dimethylsulfoxide-S)-platinum(II))

Summary for 4Z41

Entry DOI	10.2210/pdb4z41/pdb
Descriptor	Lysozyme C, 3-[2-chloranyl-2-[dimethyl(oxidanyl)-{4}-sulfanyl]-4-ethylsulfanyl-1-oxa-3{3}-thia-2{4}-platinacyclohexa-3,5-dien-6-yl]phenol, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	pt compounds, anticancer agents, lysozyme complexes, hydrolase
Biological source	Gallus gallus (Chicken)
Cellular location	Secreted: P00698
Total number of polymer chains	1
Total formula weight	15640.67
Authors	Merlino, A. (deposition date: 2015-04-01, release date: 2015-09-02, Last modification date: 2024-01-10)
Primary citation	Mugge, C.,Marzo, T.,Massai, L.,Hildebrandt, J.,Ferraro, G.,Rivera-Fuentes, P.,Metzler-Nolte, N.,Merlino, A.,Messori, L.,Weigand, W. Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding. Inorg.Chem., 54:8560-8570, 2015 Cited by PubMed: 26280387 DOI: 10.1021/acs.inorgchem.5b01238 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation