4YYZ
11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR
Summary for 4YYZ
Entry DOI | 10.2210/pdb4yyz/pdb |
Related | 4C7J 4C7K |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[(1R,2s,3S,5s,7s)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total) |
Functional Keywords | dehydrogenase inhibitor, bhsd, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845 |
Total number of polymer chains | 2 |
Total formula weight | 58935.62 |
Authors | Branden, G.,Boden, C.,Ogg, D. (deposition date: 2015-03-24, release date: 2016-02-03, Last modification date: 2024-05-08) |
Primary citation | Robb, G.R.,Boyd, S.,Davies, C.D.,Dossiter, A.G.,Goldberg, F.W.,Kemmitt, P.D.,Scott, J.S.,Swales, J.G. Design of pyrozolo-pyrimidines as 11beta-HSD1 inhibitors through optimisation of molecular electrostatic potential. Medchemcomm, 6:926-934, 2016 Cited by DOI: 10.1039/C5MD00043BPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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