4YQU

Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-31

Summary for 4YQU

Entry DOI	10.2210/pdb4yqu/pdb
Related	4YQM 4YQV
Descriptor	Glutathione S-transferase omega-1, N-{5-(azepan-1-ylsulfonyl)-2-[(ethylsulfanyl)methoxy]phenyl}acetamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	covalent inhibitor, thioltransferase, chloroacetamide, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : P78417
Total number of polymer chains	2
Total formula weight	56907.74
Authors	Stuckey, J.A. (deposition date: 2015-03-13, release date: 2016-10-12, Last modification date: 2023-09-27)
Primary citation	Ramkumar, K.,Samanta, S.,Kyani, A.,Yang, S.,Tamura, S.,Ziemke, E.,Stuckey, J.A.,Li, S.,Chinnaswamy, K.,Otake, H.,Debnath, B.,Yarovenko, V.,Sebolt-Leopold, J.S.,Ljungman, M.,Neamati, N. Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor. Nat Commun, 7:13084-13084, 2016 Cited by PubMed: 27703239 DOI: 10.1038/ncomms13084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation