4YPS

(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

Summary for 4YPS

• Entry DOI: 10.2210/pdb4yps/pdb
• Related: 4YNE
• Descriptor: High affinity nerve growth factor receptor, 4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile, SULFATE ION, ... (4 entities in total)
• Functional Keywords: trka, kinase, oncology, inhibitor complex., transfease-transferase inhibitor complex, transfease/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P04629
• Total number of polymer chains: 1
• Total formula weight: 35045.28

Authors

Kreusch, A.,Rucker, P.,Molteni, V.,Loren, J. (deposition date: 2015-03-13, release date: 2015-06-03, Last modification date: 2023-09-27)

• Primary citation: Choi, H.S.,Rucker, P.V.,Wang, Z.,Fan, Y.,Albaugh, P.,Chopiuk, G.,Gessier, F.,Sun, F.,Adrian, F.,Liu, G.,Hood, T.,Li, N.,Jia, Y.,Che, J.,McCormack, S.,Li, A.,Li, J.,Steffy, A.,Culazzo, A.,Tompkins, C.,Phung, V.,Kreusch, A.,Lu, M.,Hu, B.,Chaudhary, A.,Prashad, M.,Tuntland, T.,Liu, B.,Harris, J.,Seidel, H.M.,Loren, J.,Molteni, V.; (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.; Acs Med.Chem.Lett., 6:562-567, 2015; PubMed: 26005534; DOI: 10.1021/acsmedchemlett.5b00050

Experimental method

X-RAY DIFFRACTION (2.1012 Å)