4YP8

Irak4-inhibitor co-structure

Summary for 4YP8

Entry DOI	10.2210/pdb4yp8/pdb
Descriptor	Interleukin-1 receptor-associated kinase 4, N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
Functional Keywords	kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9NWZ3
Total number of polymer chains	4
Total formula weight	137775.07
Authors	Fischmann, T.O. (deposition date: 2015-03-12, release date: 2015-05-20, Last modification date: 2023-09-27)
Primary citation	McElroy, W.T.,Tan, Z.,Ho, G.,Paliwal, S.,Li, G.,Seganish, W.M.,Tulshian, D.,Tata, J.,Fischmann, T.O.,Sondey, C.,Bian, H.,Bober, L.,Jackson, J.,Garlisi, C.G.,Devito, K.,Fossetta, J.,Lundell, D.,Niu, X. Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation. Acs Med.Chem.Lett., 6:677-682, 2015 Cited by PubMed: 26101573 DOI: 10.1021/acsmedchemlett.5b00106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.641 Å)

Structure validation