4YMQ
X-ray co-structure of nuclear receptor ROR-GAMMAT + SRC2 peptide with a benzothiadiazole dioxide inverse agonist
Summary for 4YMQ
Entry DOI | 10.2210/pdb4ymq/pdb |
Descriptor | Nuclear receptor ROR-gamma, SODIUM ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | rorgt, nuclear hormone receptor, benzothiadiazole dioxide, inverse agonist |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 1 |
Total formula weight | 33155.09 |
Authors | |
Primary citation | Muegge, I.,Collin, D.,Cook, B.,Hill-Drzewi, M.,Horan, J.,Kugler, S.,Labadia, M.,Li, X.,Smith, L.,Zhang, Y. Discovery of 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide analogs as new RORC modulators. Bioorg.Med.Chem.Lett., 25:1892-1895, 2015 Cited by PubMed: 25840886DOI: 10.1016/j.bmcl.2015.03.042 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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