4YHT

bRaf complexed with an inhibitor

Summary for 4YHT

• Entry DOI: 10.2210/pdb4yht/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, GLYCEROL, 3-[(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-(morpholin-4-yl)benzenesulfonamide, ... (4 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 62987.36

Authors

Shewchuk, L.M.,Lawhorn, B.G. (deposition date: 2015-02-27, release date: 2016-03-16, Last modification date: 2024-02-28)

• Primary citation: Lawhorn, B.G.,Philp, J.,Graves, A.P.,Shewchuk, L.,Holt, D.A.,Gatto, G.J.,Kallander, L.S.; GSK114: A selective inhibitor for elucidating the biological role of TNNI3K.; Bioorg.Med.Chem.Lett., 26:3355-3358, 2016; PubMed: 27246618; DOI: 10.1016/j.bmcl.2016.05.033

Experimental method

X-RAY DIFFRACTION (3.05 Å)