4YAB
Crystal structure of TRIM24 PHD-bromodomain complexed with 1-methyl-5-(2-methyl-1 3-thiazol-4-yl)-2 3-dihydro-1H-indol-2-one (1)
Summary for 4YAB
Entry DOI | 10.2210/pdb4yab/pdb |
Related | 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 |
Descriptor | Transcription intermediary factor 1-alpha, ZINC ION, 1-methyl-5-(2-methyl-1,3-thiazol-4-yl)-1,3-dihydro-2H-indol-2-one, ... (5 entities in total) |
Functional Keywords | center for biomolecular structure and function, bromodomain, trim24, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O15164 |
Total number of polymer chains | 2 |
Total formula weight | 43579.18 |
Authors | Poncet-Montange, G.,Palmer, W.,Jones, P. (deposition date: 2015-02-17, release date: 2015-06-24, Last modification date: 2023-09-27) |
Primary citation | Palmer, W.S.,Poncet-Montange, G.,Liu, G.,Petrocchi, A.,Reyna, N.,Subramanian, G.,Theroff, J.,Yau, A.,Kost-Alimova, M.,Bardenhagen, J.P.,Leo, E.,Shepard, H.E.,Tieu, T.N.,Shi, X.,Zhan, Y.,Zhao, S.,Barton, M.C.,Draetta, G.,Toniatti, C.,Jones, P.,Geck Do, M.,Andersen, J.N. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J.Med.Chem., 59:1440-1454, 2016 Cited by PubMed: 26061247DOI: 10.1021/acs.jmedchem.5b00405 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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