4XY2

Crystal structure of PDE10A in complex with ASP9436

Summary for 4XY2

Entry DOI	10.2210/pdb4xy2/pdb
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	79817.77
Authors	Amano, Y.,Honbou, K. (deposition date: 2015-02-02, release date: 2015-06-17, Last modification date: 2024-03-20)
Primary citation	Hamaguchi, W.,Masuda, N.,Miyamoto, S.,Kikuchi, S.,Narazaki, F.,Shiina, Y.,Seo, R.,Amano, Y.,Mihara, T.,Moriguchi, H.,Hattori, K. Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436 Bioorg.Med.Chem., 23:3351-3367, 2015 Cited by PubMed: 25960322 DOI: 10.1016/j.bmc.2015.04.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation