4XXR

Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase

Summary for 4XXR

Entry DOI	10.2210/pdb4xxr/pdb
Descriptor	CTX-M-14 Class A Beta-Lactamase, POTASSIUM ION, [(1,2,3,4,5-eta)-1-(4-{[(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... (6 entities in total)
Functional Keywords	beta-lactamase organometallic ruthenocene ctx-m-14, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	59106.29
Authors	Lewandowski, E.M.,Chen, Y. (deposition date: 2015-01-30, release date: 2015-03-18, Last modification date: 2023-09-27)
Primary citation	Lewandowski, E.M.,Skiba, J.,Torelli, N.J.,Rajnisz, A.,Solecka, J.,Kowalski, K.,Chen, Y. Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated beta-lactam antibiotic. Chem.Commun.(Camb.), 51:6186-6189, 2015 Cited by PubMed: 25753149 DOI: 10.1039/c5cc00904a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.18 Å)

Structure validation