4XWK
P-glycoprotein co-crystallized with BDE-100
Summary for 4XWK
Entry DOI | 10.2210/pdb4xwk/pdb |
Descriptor | Multidrug resistance protein 1A, 2,4-dibromophenyl 2,4,6-tribromophenyl ether (2 entities in total) |
Functional Keywords | membrane protein, transporter, hydrolase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 142484.64 |
Authors | McGrath, A.P.,Rees, S.D.,Chang, G. (deposition date: 2015-01-28, release date: 2016-04-27, Last modification date: 2023-09-27) |
Primary citation | Nicklisch, S.C.,Rees, S.D.,McGrath, A.P.,Gokirmak, T.,Bonito, L.T.,Vermeer, L.M.,Cregger, C.,Loewen, G.,Sandin, S.,Chang, G.,Hamdoun, A. Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Sci Adv, 2:e1600001-e1600001, 2016 Cited by PubMed: 27152359DOI: 10.1126/sciadv.1600001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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