4XRM

homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA

Summary for 4XRM

• Entry DOI: 10.2210/pdb4xrm/pdb
• Descriptor: DNA (5'-D(P*AP*GP*CP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*GP*C)-3'), Homeobox protein Meis2, ... (5 entities in total)
• Functional Keywords: tale homeobox, meis, complex, dna, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O14770
• Total number of polymer chains: 4
• Total formula weight: 25694.44

Authors

Morgunova, E.,Jorma, A.,Yin, Y.,Nitta, K.R.,Dave, K.,Enge, M.,Kivioja, T.,Popov, A.,Taipale, J. (deposition date: 2015-01-21, release date: 2015-11-04, Last modification date: 2024-01-10)

• Primary citation: Jolma, A.,Yin, Y.,Nitta, K.R.,Dave, K.,Popov, A.,Taipale, M.,Enge, M.,Kivioja, T.,Morgunova, E.,Taipale, J.; DNA-dependent formation of transcription factor pairs alters their binding specificity.; Nature, 527:384-388, 2015; PubMed: 26550823; DOI: 10.1038/nature15518

Experimental method

X-RAY DIFFRACTION (1.6 Å)