4XE1

Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN

Summary for 4XE1

Entry DOI	10.2210/pdb4xe1/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	cytoplasm, lyase, inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30327.88
Authors	Alterio, V.,De Simone, G. (deposition date: 2014-12-21, release date: 2015-03-18, Last modification date: 2024-01-10)
Primary citation	Alterio, V.,Tanc, M.,Ivanova, J.,Zalubovskis, R.,Vozny, I.,Monti, S.M.,Di Fiore, A.,De Simone, G.,Supuran, C.T. X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor. Org.Biomol.Chem., 13:4064-4069, 2015 Cited by PubMed: 25733161 DOI: 10.1039/c4ob02648a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation