4XCU
Crystal Structure of FGFR4 with an Irreversible Inhibitor
Summary for 4XCU
Entry DOI | 10.2210/pdb4xcu/pdb |
Descriptor | Fibroblast growth factor receptor 4, SULFATE ION, N-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)propanamide, ... (4 entities in total) |
Functional Keywords | receptor tyrosine kinase, hepatocellular carcinoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34474.67 |
Authors | Kim, J.L.,Miduturu, C.,Hodous, B.,Brooijmans, N.,Bifulco, N.,Guzi, T. (deposition date: 2014-12-18, release date: 2015-04-01, Last modification date: 2018-12-12) |
Primary citation | Hagel, M.,Miduturu, C.,Sheets, M.,Rubin, N.,Weng, W.,Stransky, N.,Bifulco, N.,Kim, J.L.,Hodous, B.,Brooijmans, N.,Shutes, A.,Winter, C.,Lengauer, C.,Kohl, N.E.,Guzi, T. First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway. Cancer Discov, 5:424-437, 2015 Cited by PubMed: 25776529DOI: 10.1158/2159-8290.CD-14-1029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
Download full validation report