4X7Q

PIM2 kinase in complex with Compound 1s

Summary for 4X7Q

• Entry DOI: 10.2210/pdb4x7q/pdb
• Descriptor: Serine/threonine-protein kinase pim-2, 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 69532.56

Authors

Marcotte, D.J.,Silvian, L.F. (deposition date: 2014-12-09, release date: 2015-02-11, Last modification date: 2023-09-27)

• Primary citation: Ishchenko, A.,Zhang, L.,Le Brazidec, J.Y.,Fan, J.,Chong, J.H.,Hingway, A.,Raditsis, A.,Singh, L.,Elenbaas, B.,Hong, V.S.,Marcotte, D.,Silvian, L.,Enyedy, I.,Chao, J.; Structure-based design of low-nanomolar PIM kinase inhibitors.; Bioorg.Med.Chem.Lett., 25:474-480, 2015; PubMed: 25575657; DOI: 10.1016/j.bmcl.2014.12.041

Experimental method

X-RAY DIFFRACTION (2.33 Å)