4X0P

Ternary complex of human DNA polymerase theta C-terminal domain binding ddATP opposite a tetrahydrofuran AP site analog

Summary for 4X0P

• Entry DOI: 10.2210/pdb4x0p/pdb
• Related: 4X0Q
• Descriptor: DNA polymerase theta, DNA (5'-D(P*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*C)-3'), DNA (5'-D(*CP*GP*TP*TP*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), ... (6 entities in total)
• Functional Keywords: dna polymerase alternative end-joining translesion dna synthesis cancer, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 399140.66

Authors

Zahn, K.E.,Doublie, S. (deposition date: 2014-11-21, release date: 2015-03-18, Last modification date: 2023-09-27)

• Primary citation: Zahn, K.E.,Averill, A.M.,Aller, P.,Wood, R.D.,Doublie, S.; Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.; Nat.Struct.Mol.Biol., 22:304-311, 2015; PubMed: 25775267; DOI: 10.1038/nsmb.2993

Experimental method

X-RAY DIFFRACTION (3.911 Å)