4WXU

Crystal Structure of the Selenomthionine Incorporated Myocilin Olfactomedin Domain E396D Variant.

Summary for 4WXU

Entry DOI	10.2210/pdb4wxu/pdb
Related	4WXQ 4WXS
Descriptor	Myocilin, CALCIUM ION, HEXAETHYLENE GLYCOL, ... (6 entities in total)
Functional Keywords	beta propeller, 5 bladed propeller, olfactomedin, protein binding
Biological source	Homo sapiens (Human)
Cellular location	Secreted. Myocilin, C-terminal fragment: Secreted. Myocilin, N-terminal fragment: Endoplasmic reticulum: Q99972
Total number of polymer chains	1
Total formula weight	32511.68
Authors	Donegan, R.K.,Freeman, D.M.,Lieberman, R.L. (deposition date: 2014-11-14, release date: 2015-04-01)
Primary citation	Donegan, R.K.,Hill, S.E.,Freeman, D.M.,Nguyen, E.,Orwig, S.D.,Turnage, K.C.,Lieberman, R.L. Structural basis for misfolding in myocilin-associated glaucoma. Hum.Mol.Genet., 24:2111-2124, 2015 Cited by PubMed: 25524706 DOI: 10.1093/hmg/ddu730 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.092 Å)

Structure validation