4WSQ
Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with small molecule inhibitor
Summary for 4WSQ
Entry DOI | 10.2210/pdb4wsq/pdb |
Descriptor | AP2-associated protein kinase 1, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, small-molecule, catalytic domain, protein kinase, protein binding, protein kinase inhibitors, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Peripheral membrane protein : Q2M2I8 |
Total number of polymer chains | 2 |
Total formula weight | 72877.65 |
Authors | Sorrell, F.J.,Elkins, J.M.,Krojer, T.,Williams, E.,Abdul, K.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-10-28, release date: 2014-11-05, Last modification date: 2024-01-10) |
Primary citation | Sorrell, F.J.,Szklarz, M.,Abdul Azeez, K.R.,Elkins, J.M.,Knapp, S. Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. Structure, 24:401-411, 2016 Cited by PubMed: 26853940DOI: 10.1016/j.str.2015.12.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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