4WIV
Crystal Structure of the first bromodomain of human BRD4 in complex with a novel inhibitor UMB32 (N-TERT-BUTYL-2-[4-(3,5-DIMETHYL-1,2-OXAZOL-4-YL) PHENYL]IMIDAZO[1,2-A]PYRAZIN-3-AMINE)
Summary for 4WIV
Entry DOI | 10.2210/pdb4wiv/pdb |
Descriptor | Bromodomain-containing protein 4, N-tert-butyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]imidazo[1,2-a]pyrazin-3-amine, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | drug discovery, epigenesis, structure-activity relationship, tumor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15769.14 |
Authors | Xu, X.,Blacklow, S. (deposition date: 2014-09-26, release date: 2014-10-29, Last modification date: 2023-09-27) |
Primary citation | McKeown, M.R.,Shaw, D.L.,Fu, H.,Liu, S.,Xu, X.,Marineau, J.J.,Huang, Y.,Zhang, X.,Buckley, D.L.,Kadam, A.,Zhang, Z.,Blacklow, S.C.,Qi, J.,Zhang, W.,Bradner, J.E. Biased multicomponent reactions to develop novel bromodomain inhibitors. J.Med.Chem., 57:9019-9027, 2014 Cited by PubMed: 25314271DOI: 10.1021/jm501120z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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