4WB5
Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit)
Summary for 4WB5
Entry DOI | 10.2210/pdb4wb5/pdb |
Related | 4WB6 4WB7 4WB8 |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, PKI (5-24), ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | catalysis, protein kinase, adenosine triphosphate, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform 2: Cell projection, cilium, flagellum : P17612 |
Total number of polymer chains | 2 |
Total formula weight | 43539.55 |
Authors | Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Hendrickson, W.A. (deposition date: 2014-09-02, release date: 2015-01-21, Last modification date: 2023-09-27) |
Primary citation | Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Robine, N.,Darnell, R.B.,Hendrickson, W.A. Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112:1374-1379, 2015 Cited by PubMed: 25605907DOI: 10.1073/pnas.1424206112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.641 Å) |
Structure validation
Download full validation report