4WAG
Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor
Summary for 4WAG
| Entry DOI | 10.2210/pdb4wag/pdb |
| Descriptor | Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, 6-chloro-3-(3,4-dimethoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-amine (2 entities in total) |
| Functional Keywords | inhibitor, transferase |
| Biological source | Homo sapiens (Human) More |
| Cellular location | Endomembrane system: Q9UBF8 |
| Total number of polymer chains | 1 |
| Total formula weight | 65583.52 |
| Authors | Chalupska, D.,Boura, E. (deposition date: 2014-08-29, release date: 2015-05-20, Last modification date: 2017-09-06) |
| Primary citation | Mejdrova, I.,Chalupska, D.,Kogler, M.,Sala, M.,Plackova, P.,Baumlova, A.,Hrebabecky, H.,Prochazkova, E.,Dejmek, M.,Guillon, R.,Strunin, D.,Weber, J.,Lee, G.,Birkus, G.,Mertlikova-Kaiserova, H.,Boura, E.,Nencka, R. Highly Selective Phosphatidylinositol 4-Kinase III beta Inhibitors and Structural Insight into Their Mode of Action. J.Med.Chem., 58:3767-3793, 2015 Cited by PubMed: 25897704DOI: 10.1021/acs.jmedchem.5b00499 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.407 Å) |
Structure validation
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