4UX8

RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association

Summary for 4UX8

Entry DOI	10.2210/pdb4ux8/pdb
EMDB information	2712
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, GDNF FAMILY RECEPTOR ALPHA-1, GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR, ... (5 entities in total)
Functional Keywords	signaling protein, vertebrate development, human diseases, part of the ret-gfl- gfra complex
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	6
Total formula weight	269309.39
Authors	Goodman, K.,Kjaer, S.,Beuron, F.,Knowles, P.,Nawrotek, A.,Burns, E.,Purkiss, A.,George, R.,Santoro, M.,Morris, E.P.,McDonald, N.Q. (deposition date: 2014-08-19, release date: 2014-10-01, Last modification date: 2020-07-29)
Primary citation	Goodman, K.M.,Kjaer, S.,Beuron, F.,Knowles, P.P.,Nawrotek, A.,Burns, E.M.,Purkiss, A.G.,George, R.,Santoro, M.,Morris, E.P.,Mcdonald, N.Q. Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association. Cell Rep., 8:1894-, 2014 Cited by PubMed: 25242331 DOI: 10.1016/J.CELREP.2014.08.040 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (24 Å)

Structure validation