4UWB
Fibroblast growth factor receptor 1 kinase in complex with JK-P5
Summary for 4UWB
Entry DOI | 10.2210/pdb4uwb/pdb |
Related | 4UWC |
Descriptor | FIBROBLAST GROWTH FACTOR RECEPTOR 1, 1,2-ETHANEDIOL, N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-indazole-3-carboxamide, ... (5 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71443.95 |
Authors | Beeston, H.,Tucker, J.,Kankanala, J. (deposition date: 2014-08-11, release date: 2015-09-02, Last modification date: 2024-05-01) |
Primary citation | Beeston, H.S.,Klein, T.,Norman, R.A.,Tucker, J.A.,Anderson, M.,Ashcroft, A.E.,Holdgate, G.A. Validation of IMS-MS as a screening tool to identify type II kinase inhibitors of FGFR1 kinase. Rapid Commun Mass Spectrom, :e9130-e9130, 2021 Cited by PubMed: 34038603DOI: 10.1002/rcm.9130 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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