4UV7
The complex structure of extracellular domain of EGFR and GC1118A
Summary for 4UV7
Entry DOI | 10.2210/pdb4uv7/pdb |
Descriptor | EPIDERMAL GROWTH FACTOR RECEPTOR, GC1118A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | transferase, receptor tyrosine kinase, antibody |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 3 |
Total formula weight | 118519.41 |
Authors | |
Primary citation | Lim, Y.,Yoo, J.,Kim, M.S.,Hur, M.,Lee, E.H.,Hur, H.S.,Lee, J.C.,Lee, S.N.,Park, T.W.,Lee, K.,Chang, K.H.,Kim, K.,Kang, Y.,Hong, K.W.,Kim, S.H.,Kim, Y.G.,Yoon, Y.,Nam, D.H.,Yang, H.,Kim, D.G.,Cho, H.S.,Won, J. Gc1118, an Anti-Egfr Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity Against High-Affinity Egfr Ligands. Mol.Cancer Ther., 15:251-, 2016 Cited by PubMed: 26586721DOI: 10.1158/1535-7163.MCT-15-0679 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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