4UT3

X-ray structure of the human PP1 gamma catalytic subunit treated with hydrogen peroxide

Summary for 4UT3

• Entry DOI: 10.2210/pdb4ut3/pdb
• Related: 4UT2
• Descriptor: SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT, MANGANESE (II) ION, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: metal center, metalloprotein, enzyme activation, phosphoprotein phosphatases, protein phosphatase 1, hydrolase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P36873 P36873
• Total number of polymer chains: 2
• Total formula weight: 74519.25

Authors

Zeh Silva, M.,Kopec, J.,Fotinou, D.,Steiner, R.A. (deposition date: 2014-07-17, release date: 2015-07-22, Last modification date: 2024-01-10)

• Primary citation: Santos, C.X.,Hafstad, A.D.,Beretta, M.,Zhang, M.,Molenaar, C.,Kopec, J.,Fotinou, D.,Murray, T.V.,Cobb, A.M.,Martin, D.,Zeh Silva, M.,Anilkumar, N.,Schroder, K.,Shanahan, C.M.,Brewer, A.C.,Brandes, R.P.,Blanc, E.,Parsons, M.,Belousov, V.,Cammack, R.,Hider, R.C.,Steiner, R.A.,Shah, A.M.; Targeted Redox Inhibition of Protein Phosphatase 1 by Nox4 Regulates Eif2Alpha-Mediated Stress Signaling.; Embo J., 35:319-, 2016; PubMed: 26742780; DOI: 10.15252/EMBJ.201592394

Experimental method

X-RAY DIFFRACTION (2.19 Å)