5A63

Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.

Replaces:  4UPC

Summary for 5A63

• Entry DOI: 10.2210/pdb5a63/pdb
• EMDB information: 3061
• Descriptor: Nicastrin, Presenilin-1, Gamma-secretase subunit APH-1A, ... (8 entities in total)
• Functional Keywords: hydrolase, cryo-em, human gamma-secretase, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 177972.24

Authors

Bai, X.,Yan, C.,Yang, G.,Lu, P.,Ma, D.,Sun, L.,Zhou, R.,Scheres, S.H.W.,Shi, Y. (deposition date: 2015-06-24, release date: 2015-08-05, Last modification date: 2020-07-29)

• Primary citation: Bai, X.,Yan, C.,Yang, G.,Lu, P.,Ma, D.,Sun, L.,Zhou, R.,Scheres, S.H.W.,Shi, Y.; An Atomic Structure of Human Gamma-Secretase; Nature, 525:212-, 2015; PubMed: 26280335; DOI: 10.1038/NATURE14892

Experimental method

ELECTRON MICROSCOPY (3.4 Å)