4UND
HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR TALAZOPARIB
Summary for 4UND
Entry DOI | 10.2210/pdb4und/pdb |
Descriptor | POLY [ADP-RIBOSE] POLYMERASE 1, (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, SODIUM ION, ... (4 entities in total) |
Functional Keywords | transferase, protein-inhibitor complex, adp-ribosylation, dna repair |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: P09874 |
Total number of polymer chains | 2 |
Total formula weight | 84501.17 |
Authors | Karlberg, T.,Thorsell, A.G.,Ekblad, T.,Klepsch, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Schuler, H. (deposition date: 2014-05-27, release date: 2015-06-17, Last modification date: 2024-01-10) |
Primary citation | Thorsell, A.G.,Ekblad, T.,Karlberg, T.,Low, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Cohen, M.S.,Schuler, H. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60:1262-1271, 2017 Cited by PubMed: 28001384DOI: 10.1021/acs.jmedchem.6b00990 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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