4UCH

Structure of human nNOS R354A G357D mutant heme domain in complex with 3-(((2-((2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL)ETHYL)AMINO)METHYL) BENZONITRILE

Summary for 4UCH

Entry DOI	10.2210/pdb4uch/pdb
Descriptor	NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywords	oxidoreductase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein: P29475
Total number of polymer chains	2
Total formula weight	100072.67
Authors	Li, H.,Poulos, T.L. (deposition date: 2014-12-03, release date: 2014-12-24, Last modification date: 2023-12-20)
Primary citation	Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58:1067-, 2015 Cited by PubMed: 25489882 DOI: 10.1021/JM501719E PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation