4TVJ
HUMAN ARTD2 (PARP2) - CATALYTIC DOMAIN IN COMPLEX WITH OLAPARIB
Summary for 4TVJ
Entry DOI | 10.2210/pdb4tvj/pdb |
Related | 3KCZ 3KJD |
Descriptor | Poly [ADP-ribose] polymerase 2, 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, GLYCEROL, ... (4 entities in total) |
Functional Keywords | poly(adp-ribose) transferase, inhibitor, adp-ribosylation, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9UGN5 |
Total number of polymer chains | 2 |
Total formula weight | 84801.05 |
Authors | Karlberg, T.,Thorsell, A.G.,Ekblad, T.,Pinto, A.F.,Schuler, H. (deposition date: 2014-06-27, release date: 2015-07-08, Last modification date: 2023-12-20) |
Primary citation | Thorsell, A.G.,Ekblad, T.,Karlberg, T.,Low, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Cohen, M.S.,Schuler, H. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60:1262-1271, 2017 Cited by PubMed: 28001384DOI: 10.1021/acs.jmedchem.6b00990 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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