4TR9

Ternary co-crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP and a small molecule inhibitor

Summary for 4TR9

• Entry DOI: 10.2210/pdb4tr9/pdb
• Related: 2pc4
• Descriptor: Fructose-bisphosphate aldolase, ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ALA-ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ... (6 entities in total)
• Functional Keywords: lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Plasmodium falciparum; More
• Total number of polymer chains: 10
• Total formula weight: 165823.37

Authors

Bosch, G.,Weltzer, R.,O'Malley, K.,Bosch, J. (deposition date: 2014-06-15, release date: 2015-08-26, Last modification date: 2023-09-27)

• Primary citation: Nemetski, S.M.,Cardozo, T.J.,Bosch, G.,Weltzer, R.,O'Malley, K.,Ejigiri, I.,Kumar, K.A.,Buscaglia, C.A.,Nussenzweig, V.,Sinnis, P.,Levitskaya, J.,Bosch, J.; Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.; Malar.J., 14:324-324, 2015; PubMed: 26289816; DOI: 10.1186/s12936-015-0834-9

Experimental method

X-RAY DIFFRACTION (2.111 Å)