4RSC
Crystal structure of RPE65 in complex with emixustat and palmitate
Summary for 4RSC
Entry DOI | 10.2210/pdb4rsc/pdb |
Related | 3FSN 4F2Z 4RSE |
Descriptor | Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (5 entities in total) |
Functional Keywords | 7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, retinoid isomerase, smooth endoplasmic reticulum, isomerase |
Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
Cellular location | Cytoplasm: Q28175 |
Total number of polymer chains | 2 |
Total formula weight | 123231.68 |
Authors | Kiser, P.D.,Shi, W.,Palczewski, K. (deposition date: 2014-11-07, release date: 2015-04-15, Last modification date: 2023-09-20) |
Primary citation | Kiser, P.D.,Zhang, J.,Badiee, M.,Li, Q.,Shi, W.,Sui, X.,Golczak, M.,Tochtrop, G.P.,Palczewski, K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11:409-415, 2015 Cited by PubMed: 25894083DOI: 10.1038/nchembio.1799 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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