4RKO
Crystal structure of thrombin mutant S195T bound with PPACK
Summary for 4RKO
Entry DOI | 10.2210/pdb4rko/pdb |
Related | 1SHH 4RKJ |
Related PRD ID | PRD_000020 |
Descriptor | Thrombin heavy chain, Thrombin light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (8 entities in total) |
Functional Keywords | trypsin-like proteases, catalysis, allosteric regulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 35732.25 |
Authors | Pelc, A.L.,Chen, Z.,Gohara, D.W.,Vogt, A.D.,Pozzi, N.,Di Cera, E. (deposition date: 2014-10-13, release date: 2015-03-11, Last modification date: 2023-09-20) |
Primary citation | Pelc, L.A.,Chen, Z.,Gohara, D.W.,Vogt, A.D.,Pozzi, N.,Di Cera, E. Why ser and not thr brokers catalysis in the trypsin fold. Biochemistry, 54:1457-1464, 2015 Cited by PubMed: 25664608DOI: 10.1021/acs.biochem.5b00014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
Download full validation report