4RIK

Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77

Summary for 4RIK

Entry DOI	10.2210/pdb4rik/pdb
Descriptor	Alpha-synuclein (2 entities in total)
Functional Keywords	amyloid, alpha-synuclein, parkinson's disease, toxic core, nac, lipid binding protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol : P37840
Total number of polymer chains	1
Total formula weight	815.95
Authors	Guenther, E.L.,Sawaya, M.R.,Ivanova, M.,Eisenberg, D.S. (deposition date: 2014-10-06, release date: 2015-08-26, Last modification date: 2024-04-03)
Primary citation	Rodriguez, J.A.,Ivanova, M.I.,Sawaya, M.R.,Cascio, D.,Reyes, F.E.,Shi, D.,Sangwan, S.,Guenther, E.L.,Johnson, L.M.,Zhang, M.,Jiang, L.,Arbing, M.A.,Nannenga, B.L.,Hattne, J.,Whitelegge, J.,Brewster, A.S.,Messerschmidt, M.,Boutet, S.,Sauter, N.K.,Gonen, T.,Eisenberg, D.S. Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525:486-490, 2015 Cited by PubMed: 26352473 DOI: 10.1038/nature15368 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.854 Å)

Structure validation