4RHX

Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

Summary for 4RHX

• Entry DOI: 10.2210/pdb4rhx/pdb
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, [2-([2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]{2-[(2-oxoethyl)(2-phosphonoethyl)amino]ethyl}amino)ethyl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: 6-oxopurine phosphoribosyltransferase, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 90739.57

Authors

Eng, W.S.,Hockova, D.,Spacek, P.,West, N.P.,Woods, K.,Naesens, L.M.J.,Keough, D.T.,Guddat, L.W. (deposition date: 2014-10-03, release date: 2015-05-20, Last modification date: 2024-02-28)

• Primary citation: Eng, W.S.,Hockova, D.,Spacek, P.,Janeba, Z.,West, N.P.,Woods, K.,Naesens, L.M.,Keough, D.T.,Guddat, L.W.; First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.; J.Med.Chem., 58:4822-4838, 2015; PubMed: 25915781; DOI: 10.1021/acs.jmedchem.5b00611

Experimental method

X-RAY DIFFRACTION (2.0322 Å)