4RCP
Crystal structure of Plk1 Polo-box domain in complex with PL-2
Summary for 4RCP
Entry DOI | 10.2210/pdb4rcp/pdb |
Related PRD ID | PRD_001254 |
Descriptor | Serine/threonine-protein kinase PLK1, PL-2, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | polo-box domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 2 |
Total formula weight | 27628.45 |
Authors | Lee, W.C.,Song, J.H.,Kim, H.Y. (deposition date: 2014-09-16, release date: 2014-11-12, Last modification date: 2015-01-21) |
Primary citation | Ahn, M.,Han, Y.H.,Park, J.E.,Kim, S.,Lee, W.C.,Lee, S.J.,Gunasekaran, P.,Cheong, C.,Shin, S.Y.,Kim, H.Y.,Ryu, E.K.,Murugan, R.N.,Kim, N.H.,Bang, J.K. A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1. J.Med.Chem., 58:294-304, 2015 Cited by PubMed: 25347203DOI: 10.1021/jm501147g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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