4RBO

Crystal structure of a Nanog homeobox (NANOG) from Homo sapiens at 3.30 A resolution

Summary for 4RBO

• Entry DOI: 10.2210/pdb4rbo/pdb
• Descriptor: Putative homeobox protein NANOGP8, 5'-D(*GP*GP*CP*CP*CP*AP*TP*TP*CP*AP*AP*G)-3', 5'-D(*CP*TP*TP*GP*AP*AP*TP*GP*GP*GP*CP*C)-3' (3 entities in total)
• Functional Keywords: homeobox, pf00046 family, structural genomics, joint center for structural genomics, jcsg, partnership for stem cell biology, stemcell, protein structure initiative, psi-biology, dna binding protein, transcription, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q6NSW7
• Total number of polymer chains: 6
• Total formula weight: 31873.46

Authors

Joint Center for Structural Genomics (JCSG),Partnership for Stem Cell Biology (STEMCELL) (deposition date: 2014-09-12, release date: 2014-10-01, Last modification date: 2023-02-01)

• Primary citation: Hayashi, Y.,Caboni, L.,Das, D.,Yumoto, F.,Clayton, T.,Deller, M.C.,Nguyen, P.,Farr, C.L.,Chiu, H.J.,Miller, M.D.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Tomoda, K.,Conklin, B.R.,Wilson, I.A.,Yamanaka, S.,Fletterick, R.J.; Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.; Proc.Natl.Acad.Sci.USA, 112:4666-4671, 2015; PubMed: 25825768; DOI: 10.1073/pnas.1502855112

Experimental method

X-RAY DIFFRACTION (3.3 Å)