4RA0

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

Summary for 4RA0

Entry DOI	10.2210/pdb4ra0/pdb
Descriptor	Growth arrest-specific protein 6, Tyrosine-protein kinase receptor UFO, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	axl, gas6, cancer, metastasis, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	132492.68
Authors	Kariolis, M.S.,Kapur, S.,Mathews, I.I.,Cochran, J.R. (deposition date: 2014-09-09, release date: 2014-09-24, Last modification date: 2023-09-20)
Primary citation	Kariolis, M.S.,Miao, Y.R.,Jones, D.S.,Kapur, S.,Mathews, I.I.,Giaccia, A.J.,Cochran, J.R. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat.Chem.Biol., 10:977-983, 2014 Cited by PubMed: 25242553 DOI: 10.1038/nchembio.1636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.07 Å)

Structure validation