4R6A

Crystal structure of human TLR8 in complex with Hybrid-2

Summary for 4R6A

• Entry DOI: 10.2210/pdb4r6a/pdb
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: rna recognition, ssrna, leucine rich repeat, rna receptor, innate immunity, glycosylation, secreted, structure-based ligand design, vaccine adjuvants, antiviral and antitumor drug binding, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 192351.16

Authors

Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2014-08-22, release date: 2015-08-26, Last modification date: 2020-07-29)

• Primary citation: Ganapathi, L.,Haren, S.V.,Dowling, D.J.,Bergelson, I.,Shukla, N.M.,Malladi, S.S.,Balakrishna, R.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A.,Levy, O.; Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)